Quinacrine dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 69-05-6 | Cat. No. | BCP49707 |
| Name | Quinacrine dihydrochloride | ||
| Synonyms | Quinacrine 2HCl;Mepacrine dihydrochloride; SN-390 dihydrochloride; | ||
| SMILES | CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl | ||
| Chemical Name | |||
| Formula | C23H32Cl3N3O | M. Wt | 472.88 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53. | ||
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