ZLDI-8 New
Data Sheet
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| CAS No. | 667880-38-8 | Cat. No. | BCP36163 |
| Name | ZLDI-8 | ||
| Synonyms | ZLDI 8; ZLDI8; | ||
| SMILES | CC1=CC(=C(C=C1)OCCN2C(=C(C3=CC=CC=C32)C=C4C(=O)NC(=S)NC4=O)C)C | ||
| Chemical Name | |||
| Formula | C24H23N3O3S | M. Wt | 433.52 |
| Purity | 98％ | Storage | Store at 4-8°C |
| Description | ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM. | ||
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