ZLDI-8
| CAS No. | 667880-38-8 | Cat. No. | BCP36163 |
| Name | ZLDI-8 | ||
| Synonyms | ZLDI 8; ZLDI8; | ||
| Formula | C24H23N3O3S | M. Wt | 433.52 |
| Description | ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM. | ||
| Pathways | Protease/Metabolic Enzyme Wnt/Stem Cell | ||
| Targets | Phosphatase Notch | ||
Structure
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