Cyclophosphamide hydrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 6055-19-2 | Cat. No. | BCP22663 |
| Name | Cyclophosphamide hydrate | ||
| Synonyms | Cyclophosphamide monohydrate; | ||
| SMILES | ClCCN(CCCl)P1(OCCCN1)=O.[H]O[H] | ||
| Chemical Name | |||
| Formula | C7H17Cl2N2O3P | M. Wt | 279.1 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.Cyclophosphamide is used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome and following organ transplant. It is taken by mouth or injection into a vein. The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively). This is irreversible and leads to cell apoptosis. | ||
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