Cyclophosphamide hydrate

CAS No.	6055-19-2	Cat. No.	BCP22663
Name	Cyclophosphamide hydrate
Synonyms	Cyclophosphamide monohydrate;
Formula	C7H17Cl2N2O3P	M. Wt	279.1

Description	Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.Cyclophosphamide is used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome and following organ transplant. It is taken by mouth or injection into a vein. The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively). This is irreversible and leads to cell apoptosis.
Pathways	Cell Cycle/DNA Damage
Targets	DNA Alkylator/Crosslinker

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