RAS-IN-2 New
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| CAS No. | 2765081-21-6 | Cat. No. | BCP49648 |
| Name | RAS-IN-2 | ||
| Synonyms | RMC6236;RMC 6236;RMC-6236;RAS Inhibitor A122; | ||
| SMILES | CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C)C(C)OC)(C)C)NC(=O)C8CC8C | ||
| Chemical Name | |||
| Formula | C44H58N8O5S | M. Wt | 811.06 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RAS-IN-2 (RMC-6236) is an orally bioavailable pan-RAS inhibitor. RMC-6236 binds to an intracellular chaperone protein, cyclophilin A (CypA). The resulting inhibitory binary complex binds to active, GTP-bound RAS to form a tri-complex. This tri-complex inhibits RAS-dependent signaling and inhibits the proliferation of tumor cells in which RAS is overexpressed and/or mutated. | ||
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