RPI-1

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP08977CAS No. ：269730-03-2Purity：98%

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CAS No.	269730-03-2	Cat. No.	BCP08977
Name	RPI-1
Synonyms	RPI1;RPI 1;
SMILES
Chemical Name
Formula	C17H15NO4	M. Wt	297.31
Purity	98%	Storage	Store at 4-8°C
Description	RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. Recently it was discover that the compound also inhibits c-Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus not surprisingly RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size (IC50 = 24.5 + 0.5 microM). Compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity. It appears that " Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes ?-catenin transcriptional activity to drive thyrocyte neoplastic transformation". It appears that we do not have anything specific in Ret area. Handbook lists RPI-1 as Ret inhibitor.