SPP-86 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1357349-91-7 | Cat. No. | BCP46432 |
| Name | SPP-86 | ||
| Synonyms | SPP 86; SPP86; | ||
| SMILES | CC(C)N1C2=NC=NC(=C2C(=N1)C#CC3=CC=CC=C3)N | ||
| Chemical Name | |||
| Formula | C16H15N5 | M. Wt | 277.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. | ||
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