Alsterpaullone
| CAS No. | 237430-03-4 | Cat. No. | BCP33241 |
| Name | Alsterpaullone | ||
| Synonyms | 9-Nitropaullone; NSC 705701; NSC705701; NSC-705701; | ||
| Formula | C16H11N3O3 | M. Wt | 293.28 |
| Description | Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the treatment of neurodegenerative and proliferative disorders. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR Wnt/Stem Cell | ||
| Targets | GSK3 CDK | ||
Structure
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