TL 12-186 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2250025-88-6 | Cat. No. | BCP49644 |
| Name | TL 12-186 | ||
| Synonyms | TL12-186;TL12186; | ||
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O | ||
| Chemical Name | |||
| Formula | C44H51ClN10O9S | M. Wt | 931.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM). | ||
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