TL 12-186
| CAS No. | 2250025-88-6 | Cat. No. | BCP49644 |
| Name | TL 12-186 | ||
| Synonyms | TL12-186;TL12186; | ||
| Formula | C44H51ClN10O9S | M. Wt | 931.46 |
| Description | TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM). | ||
| Pathways | Others Pathway | ||
| Targets | PROTAC | ||
Structure
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