Pexidartinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1029044-16-3 | Cat. No. | BCP15183 |
| Name | Pexidartinib | ||
| Synonyms | PLX 3397;PLX3397;PL-X3397; | ||
| SMILES | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F | ||
| Chemical Name | |||
| Formula | C20H15ClF3N5 | M. Wt | 417.81 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pexidartinib, also know as PLX-3397, is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. | ||
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