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NBI-74330 Chemical Structure

NBI-74330

Data Sheet For research use only. Not for human use.
Cat. No. :BCP34091CAS No. :855527-92-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 855527-92-3 Cat. No. BCP34091
Name NBI-74330
Synonyms NBI 74330; NBI74330;
SMILES CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC(=C(C=C5)F)C(F)(F)F
Chemical Name
Formula C32H27F4N5O3 M. Wt 605.58
Purity 98% Storage Store at 4-8°C
Description NBI-74330 is an antagonist of CXC chemokine receptor 3 (CXCR3) with IC50 values of 7nM to18nM. NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice. Chemokine receptor CXCR3 promotes growth of glioma. CXCR3 antagonism exerts a direct anti-glioma effect and this receptor may be a potential therapeutic target for treating human GBM.
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