LY2109761

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02824CAS No. ：700874-71-1Purity：98%

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CAS No.	700874-71-1	Cat. No.	BCP02824
Name	LY2109761
Synonyms	LY-2109761;LY 2109761;
SMILES
Chemical Name
Formula	C26H27N5O2	M. Wt	441.52
Purity	98%	Storage	Store at 4-8°C
Description	LY2109761 treatment induces a dose-dependent low-anchorage growth inhibition of L3.6pl/GLT cells, leading to ~33% or 73% inhibition at 2 μM and 20 μM, respectively, which can be strongly enhanced when combined with gemcitabine in combination index value of 0.36581. Blocking TβRI/II kinase activity with LY2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation.LY2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression.LY2109761 pretreatment enhances radiosensitivity of glioblastoma cells via TGF-β signaling blockage. LY2109761 (10 μM) reduces the self-renewal and proliferation of GBM-derived cancer stem–like cells (CSLC), which can be significantly enhanced when c