R 112
Data Sheet
For research use only. Not for human use.
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| CAS No. | 575474-82-7 | Cat. No. | BCP20695 |
| Name | R 112 | ||
| Synonyms | R 112 (pharMaceutical);R112; R-112; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H13FN4O2 | M. Wt | 312.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L). | ||
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