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PI-103 Chemical Structure

PI-103

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01923CAS No. :371935-74-9Purity:98%
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  • Publications Citing of Biochempartner's PI-103
  • Chemical Properties&Biological Activity
CAS No. 371935-74-9 Cat. No. BCP01923
Related Products 371935-79-4(PI-103 Hydrochloride) PI-103(PI-103 hydrobromide)
Name PI-103
Synonyms PI 103;PI103;
SMILES
Chemical Name
Formula C19H16N4O3 M. Wt 348.36
Purity 98% Storage Store at 4-8°C
Description PI-103 potently inhibits both the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. PI-103 inhibits constitutive and growth factor-induced PI3K/Akt, as well as mTORC1 activation. In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 inhibits p110α >200-fold more potently than p110β. PI-103 also potently blocks production of PI(3,4)P2 and PIP3 in adipocytes and PIP3 in myotubes.PI-103 inhibits phosphorylation of Akt with an IC95 100-fold lower than that for LY294002. Strikingly, PI-103 completely protects animals from insulin-stimulated decline in blood glucose. PI-103 has additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells.
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