PI-103
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS No. | 371935-74-9 | Cat. No. | BCP01923 |
Related Products | 371935-79-4(PI-103 Hydrochloride) PI-103(PI-103 hydrobromide) | ||
Name | PI-103 | ||
Synonyms | PI 103;PI103; | ||
SMILES | |||
Chemical Name | |||
Formula | C19H16N4O3 | M. Wt | 348.36 |
Purity | 98% | Storage | Store at 4-8°C |
Description | PI-103 potently inhibits both the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. PI-103 inhibits constitutive and growth factor-induced PI3K/Akt, as well as mTORC1 activation. In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 inhibits p110α >200-fold more potently than p110β. PI-103 also potently blocks production of PI(3,4)P2 and PIP3 in adipocytes and PIP3 in myotubes.PI-103 inhibits phosphorylation of Akt with an IC95 100-fold lower than that for LY294002. Strikingly, PI-103 completely protects animals from insulin-stimulated decline in blood glucose. PI-103 has additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. |
Recommend Products
More >-
Nab-sirolimus
Cat. No.:BCP49207
No.:1402453-65-9
Product Details -
-
PI3K/mTOR Inhibitor-2
Cat. No.:BCP48401
No.:1848242-58-9
Product Details -
-
Camonsertib
Cat. No.:BCP46512
No.:2417489-10-0
Product Details -
-
NV-5138 hydrochloride
Cat. No.:BCP46023
No.:NV5138HCl
Product Details -
Panulisib
Cat. No.:BCP44105
No.:1356033-60-7
Product Details -
-
-
-
PI-103 Hydrochloride
Cat. No.:BCP36117
No.:371935-79-4
Product Details -
-
mTOR inhibitor-1
Cat. No.:BCP32690
No.:468747-17-3
Product Details -
AZD8055 D(-)-Tartaric Acid
Cat. No.:BCP25959
No.:1201799-04-3
Product Details -
AZD8055 Fumaric acid
Cat. No.:BCP25958
No.:1201799-05-4
Product Details -
Vistusertib sulfate
Cat. No.:BCP25580
No.:AZD2014
Product Details -
-
RapaLink-1
Cat. No.:BCP25153
No.:1887095-82-0
Product Details -
Tags:PI-103 supplier,PI-103 purchase,PI-103 manufacturer,PI-103 distributor,PI-103 cost,PI-103 buy,PI-103 for sale