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Belnacasan Chemical Structure

Belnacasan

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02893CAS No. :273404-37-8Purity:98%
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  • Publications Citing of Biochempartner's Belnacasan
  • Chemical Properties&Biological Activity
CAS No. 273404-37-8 Cat. No. BCP02893
Name Belnacasan
Synonyms VX-765;VX 765;VX765;
SMILES CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
Chemical Name
Formula C24H33ClN4O6 M. Wt 508.99
Purity 98% Storage Store at 4-8°C
Description Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM.
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