JNJ-63576253 New
Data Sheet
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| CAS No. | 2110428-64-1 | Cat. No. | BCP41266 |
| Name | JNJ-63576253 | ||
| Synonyms | TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; | ||
| SMILES | C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C23H21F3N6O2S | M. Wt | 502.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TRC253, also known as JNJ63576253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells. | ||
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