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AOH1996 Chemical Structure

AOH1996

Data Sheet For research use only. Not for human use.
Cat. No. :BCP49555CAS No. :2089314-64-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2089314-64-5 Cat. No. BCP49555
Name AOH1996
Synonyms AOH-1996;AOH 1996;
SMILES COC1=CC(=CC=C1)OC2=CC=CC=C2NC(=O)CNC(=O)C3=CC=CC4=CC=CC=C43
Chemical Name
Formula C26H22N2O4 M. Wt 426.46
Purity 98% Storage Store at 4-8°C
Description AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict (TRC). AOH1996 stabilizes the interaction of PCNA and RNA polymerase II, causing proteasome-dependent degradation of rpb1 and lethal DNA damages. AOH1996 also interferes the interaction of PCNA and its binding proteins, leading to DNA replication stress and inducing apoptosis. AOH1996 exerts synergistic effect with DNA damage agents, to inhibit tumor cells.
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