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ASN007 benzenesulfonate Chemical Structure

ASN007 benzenesulfonate

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP48484CAS No. ：2055597-39-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2055597-39-0 Cat. No. BCP48484
Related Products 2055597-12-9（ASN007）
Name ASN007 benzenesulfonate
Synonyms ASN-007 benzenesulfonate ;ASN 007 benzenesulfonate ;ERK-IN-3 benzenesulfonate;
SMILES
Chemical Name
Formula C28H31ClFN7O5S M. Wt 632.11
Purity 98% Storage Store at 4-8°C
Description ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines.
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