PT-2385 R-Enantiomer New
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| CAS No. | 1672666-67-9 | Cat. No. | BCP30945 |
| Name | PT-2385 R-Enantiomer | ||
| Synonyms | PT2385 R-Enantiomer; PT 2385 R-Enantiomer; | ||
| SMILES | CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O | ||
| Chemical Name | |||
| Formula | C17H12F3NO4S | M. Wt | 383.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. | ||
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