Gartisertib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP44100CAS No. ：1613191-99-3Purity：98%

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CAS No.	1613191-99-3	Cat. No.	BCP44100
Name	Gartisertib
Synonyms	ATR inhibitor 2;M4344; M-4344; M 4344; VX-803; VX803; VX 803; Gartisertibum;
SMILES	C1CN(CCC1C(=O)N2CCN(CC2)C3COC3)C4=C(C=NC=C4NC(=O)C5=C6N=CC(=CN6N=C5N)F)F
Chemical Name
Formula	C25H29F2N9O3	M. Wt	541.55
Purity	98%	Storage	Store at 4-8°C
Description	Gartisertib is an orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor VX-803 selectively inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, which results in the inhibition of DNA damage checkpoint activation, the disruption of DNA damage repair, and the induction of tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival; it is activated by DNA damage caused during DNA replication-associated stress.