RGFP966 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP42941CAS No. ：1396841-57-8Purity：98%

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CAS No.	1396841-57-8	Cat. No.	BCP42941
Name	RGFP966
Synonyms	RGFP-966;RGFP 966;
SMILES	C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N
Chemical Name
Formula	C21H19FN4O	M. Wt	362.4
Purity	98%	Storage	Store at 4-8°C
Description	RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Systemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine-conditioned place preference, while simultaneously enhancing long-term object-location memory within subjects. HDAC3 inhibition using a first in class selective inhibitor, RGFP966, resulted in decreased cell growth in CTCL cell lines due to increased apoptosis that was associated with DNA damage and impaired S phase progression. Selective inhibition of HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tumor cells, ultimately leading to cell death.