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Nirogacestat 结构式

Nirogacestat

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货号 :BCP24479CAS号 :1290543-63-3纯度:98%
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  • 基本信息与产品描述
CAS号 1290543-63-3 货号 BCP24479
中文名 Nirogacestat
英文名 Nirogacestat
中文别名
英文别名 PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014;
SMILES CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F
化学名称
分子式 C27H41F2N5O 分子量 489.64
纯度 98% 配送 惯例下常温包邮
产品描述 Nirogacestat is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival.
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