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LY900009 结构式

LY900009

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP27986CAS号 :209984-68-9纯度:98%
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  • 基本信息与产品描述
CAS号 209984-68-9 货号 BCP27986
中文名 LY900009
英文名 LY900009
中文别名
英文别名 LY-900009; LY 900009;
SMILES CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)O
化学名称
分子式 C23H27N3O4 分子量 409.48
纯度 98% 配送 惯例下常温包邮
产品描述 LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. LY900009 inhibited plasma levels of amyloid-β peptide in a dose-dependent manner with 80-90% inhibition observed in the 30- to 60-mg cohorts. LY900009 is an orally available GSI (Aβ: IC50= 10.9−12.1 nM; Notch: IC50 = 14.1 nM) that was developed as a candidate therapeutic drug against AD (IDENTITY trial), which failed in phase III trials.
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