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HIF

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HIF

结构式 货号 产品名称 CAS号
Izilendustat 结构式
 BCP32551 Izilendustat 1303512-02-8
Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2).
PHD-1-IN-1 结构式
 BCP47256 PHD-1-IN-1 2009343-14-8
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
ML228 结构式
 BCP46981 ML228 1357171-62-0
ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator. It potently activates HIF in vitro as well as its downstream target VEGF.
Belzutifan 结构式
 BCP32143 Belzutifan 1672668-24-4
Belzutifan is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha (HIF-2a), with potential antineoplastic activity.
Enarodustat 结构式
 BCP39690 依那度他 1262132-81-9
Enarodustat (JTZ-951) exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition.
HIF-2a Translation Inhibitor 76 结构式
 BCP38668 HIF-2a Translation Inhibitor 76 882268-69-1
HIF-2a Translation Inhibitor 76 is a cell-permeable HIF-2a translation inhibitor (IC50 value 5 µM).
TP0463518 结构式
 BCP38229 TP0463518 1558021-37-0
TP0463518 is a novel prolyl hydroxylase (PHD) 1/2/3 pan inhibitor, inducing erythropoietin (EPO) production in both the kidney and liver, increasing the HIF-2α and EPO mRNA expression levels in the kidney cortex.
HS-1793 结构式
 BCP37847 HS-1793 927885-00-5
HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells.
HIF2α-IN-2 结构式
 BCP37538 HIF2α-IN-2 1672666-82-8
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
Rac-PT2399 结构式
 BCP35881 Rac-PT2399 1672662-07-5
(Rac)-PT2399, the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM.
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