Nirogacestat
CAS号 | 1290543-63-3 | 货号 | BCP24479 |
中文名 | Nirogacestat | ||
英文名 | Nirogacestat | ||
中文别名 | |||
英文别名 | PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014; | ||
分子式 | C27H41F2N5O | 分子量 | 489.64 |
生物活性 | Nirogacestat is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival. | ||
信号通路 | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
靶 点 | Gamma secretase |
结构式
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