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CAS号 | 209986-17-4 | 货号 | BCP02178 |
中文名 | γ-Secretase Inhibitor XXI | ||
英文名 | γ-Secretase Inhibitor XXI | ||
中文别名 | |||
英文别名 | Compound E;DuPont E;g-Secretase Inhibitor XXI;gamma-Secretase Inhibitor XXI; | ||
SMILES | CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F | ||
化学名称 | |||
分子式 | C27H24F2N4O3 | 分子量 | 490.5 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Compound E is a cell-permeable inhibitor of γ-secretase (GSI), which is a multifunctional transmembrane protein complex enzymatically catalyzing the cleavage of single-pass transmembrane proteins. Compound E can inhibit Notch processing (IC50 = 2.2 nM in SupT1 cells) and β-ammyloid production in cell culture (IC50 = 0.3 nM). |
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