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RO4929097 结构式

RO4929097

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP02623CAS号 :847925-91-1纯度:98%
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  • 基本信息与产品描述
CAS号 847925-91-1 货号 BCP02623
中文名 RO4929097
英文名 RO4929097
中文别名
英文别名 R4733; R 4733; R-4733;RO-4929097;RO 4929097; RO04929097; RO-04929097; RO 04929097;
SMILES O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O
化学名称
分子式 C22H20F5N3O3 分子量 469.4
纯度 98% 配送 惯例下常温包邮
产品描述 RO4929097 decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells with EC50 of 14 nM. RO4929097 strongly inhibits Notch processing with EC50 of 5 nM in the Notch cell-based reporter assay. The potency of RO4929097 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity observed with respect to 75 other proteins of various types including receptors, ion channels, and enzymes (CEREP panel).
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