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结构式 货号 产品名称 CAS号
3,4-Diaminofurazan 结构式
BCP00227 3,4-二氨基呋扎 17220-38-1
3,4-Diaminofurazan is a building block used to prepare magnesium and zinc alkynylated salicylaldehyde-diamine Schiff base complexes.
Adavosertib 结构式
BCP01928 Adavosertib 955365-80-7
MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM.
Galunisertib 结构式
BCP02173 Galunisertib 700874-72-2
LY2157299 is a novel selective small molecule transforming growth factor beta receptor (TGF-βR) kinase inhibitor with IC50 of 86 nM and 2 nM for TβR1 and 2 nM, respectively.
Ivacaftor 结构式
BCP01857 依伐卡托 873054-44-5
Ivacaftor is a CFTR activator (IC50 of 43 ± 38 nM).
Roxadustat 结构式
BCP02523 罗沙司他 808118-40-3
Roxadustat (FG-4592) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor developed for the treatment of anemia.
Idelalisib 结构式
BCP02532 艾代拉里斯 870281-82-6
Idelalisib (CAL-101; GS-1101) is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
Linerixibat 结构式
BCP17155 Linerixibat 1345982-69-5
GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) .
WZ4002 结构式
BCP02515 WZ4002 1213269-23-8
WZ4002 is an EGFR T790M inhibitor(IC50<20nM).
Dactolisib 结构式
BCP00216 Dactolisib 915019-65-7
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells.
Vistusertib 结构式
BCP05748 维妥色替 1009298-59-2
AZD2014 is a selective inhibitor of mTOR kinase. AZD2014 decreases p4EBP1 Thr37/46, inhibits the translation initiation complex and decreases overall protein synthesis. AZD2014 also inhibits the mTORC2 biomarkers pAKTSer473 and pNDRG1 Thr346. AZD2014 inhibits proliferation and induces cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy.
Tezacaftor 结构式
BCP07173 替扎卡托 1152311-62-0
Tezacaftor, also known asVX-661, is CFTR modulator. VX-661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, Δ508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX-661 can correct trafficking of Δ508CFTR and partially restore chloride channel activity.
Dolutegravir 结构式
BCP02329 度鲁特韦 1051375-16-6
Dolutegravir is an integrase inhibitor being developed for the treatment of human immunodeficiency virus (HIV)-1 infection by GlaxoSmithKline (GSK) on behalf of Shionogi-ViiV Healthcare LLC.
Bedaquiline 结构式
BCP02829 贝达喹啉 843663-66-1
Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug.
Eprenetapopt 结构式
BCP20294 Eprenetapopt 5291-32-7
APR-246 restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
Trichostatin A 结构式
BCP01776 曲古菌素A 58880-19-6
Trichostatin A is a selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM).
EAI045 结构式
BCP17698 EAI045 1942114-09-1
EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants.
Etomoxir 结构式
BCP07911 乙莫克舍 124083-20-1
Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
LOXO-195 结构式
BCP20662 LOXO-195 2097002-61-2
LOXO-195 is a next-generation TRK kinase (TKI) inhibitor, with IC50s of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC respectively.
BMS986205 结构式
BCP20339 BMS-986205 1923833-60-6
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
Physostigmine salicylate 结构式
BCP25378 水杨酸毒扁豆碱 57-64-7
Physostigmine salicylate is a reversible cholinesterase inhibitor, a parasympathomimetic alkaloid.
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