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CAS号 | 292632-98-5 | 货号 | BCP16163 |
中文名 | L685458 | ||
英文名 | L685458 | ||
中文别名 | |||
英文别名 | L-685458;L 685458; | ||
SMILES | |||
化学名称 | |||
分子式 | C39H52N4O6 | 分子量 | 672.85 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro. |
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