所有产品分类
所有产品
信号通路
- Angiogenesis/Protein Tyrosine Kinase
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- Epigenetics
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GPCR/G Protein
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Neuro Signaling Pathway
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Protease/Metabolic Enzyme
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研究领域
- Metabolic Disease
- Neurological Disease
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- Diabetes
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- Inflammation
- Infection
- Cancer
天然产物
抗体
多肽
催化剂
杂质对照品
医药中间体
基础原料
RET
结构式 | 货号 | 产品名称 | CAS号 |
---|
BCP49314 | APS-03118 新 | APS-03118 | |
APS03118 is a novel next-generation RET inhibitor which is potent against a range of RET fusions and mutations including both SFMs and gatekeeper mutations.
|
BCP48539 | BT44 新 | 924759-42-2 | |
BT44 is a novel RET agonist for the treatment of experimental neuropathies.
|
BCP46432 | SPP-86 新 | 1357349-91-7 | |
SPP-86 is a potent RET inhibitor.
|
BCP43814 | TPX-0046 新 | TPX0046 | |
TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.
|
BCP37566 | Ret V804M-IN-1 新 | 2414909-94-5 | |
Ret V804M-IN-1 is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM.
|
BCP31224 | cis-Pralsetinib 新 | 2097132-93-7 | |
cis-Pralsetinib is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.
|
BCP30970 | GUN55146 新 | 2222755-14-6 | |
LOXO-292 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
|
BCP29411 | 拉西替尼 新 | 2097132-94-8 | |
Pralsetinib (BLU-667) is a highly potent and selective RET inhibitor with an IC50 of 0.4 nM for wild type RET kinase.
|
BCP23560 | RET Kinase inhibitor 1 新 | 1627856-64-7 | |
GSK3179106 is a potent, selective, first-in-class and gut-restricted RET kinase inhibitor with IC50 of 0.4 and 11 nM in the biochemical assay and cellular assay respectively, 273-fold selectivity over KDR.
|
BCP25106 | AD80 | 1384071-99-1 | |
AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity.
|