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CAS号 | 677772-84-8 | 货号 | BCP43170 |
中文名 | MRK 560 | ||
英文名 | MRK 560 | ||
中文别名 | |||
英文别名 | MRK 560; MRK-560; | ||
SMILES | C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl | ||
化学名称 | |||
分子式 | C19H17ClF5NO4S2 | 分子量 | 517.92 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | MRK 560 is a γ-secretase inhibitor, which selectively inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. MRK 560 reduces levels of Aβ in vitro (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM) and attenuates plaque deposition. This compound is orally bioavailable. |
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