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PROTAC

结构式 货号 产品名称 CAS号
ARV393 结构式
 BCP49670 ARV393 2851885-95-3
ARV-393 is an orally active PROTAC degrader targeting BCL6. ARV-393 utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models.
Boc-NH-PEG(3)-COOH 结构式
 BCP49651 N-叔丁氧羰基-四聚乙二醇-乙酸 876345-13-0
Boc-NH-PEG(3)-COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates and a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Luxdegalutamide 结构式
 BCP49650 Luxdegalutamide 2750830-09-0
Luxdegalutamide is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. Luxdegalutamide degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.
TL 12-186 结构式
 BCP49644 TL 12-186 2250025-88-6
TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.
Tos-PEG3-alcohol 结构式
 BCP49618 三乙二醇单对甲苯磺酸酯 77544-68-4
Tos-PEG3 is a polyethylene glycol (PEG)-based PROTAC linker. Tos-PEG3 can be used in the synthesis of a series of PROTACs.
Polyethyleneglycolbis(methanesulfonate) 结构式
 BCP49583 聚乙二醇二甲磺酸酯 52410-74-9
Ethylene dimethanesulfonate is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Poly(ethylene glycol) bisazide 结构式
 BCP49582 聚氧乙烯二叠氮化物 82055-94-5
Pentaerythritol propoxylate may be used as a precipitant in reservoir solution for the crystallization of Phosphate Transporter(PiPT) and Aggregation Suppressing Protein A(AgsA).
Pentaethylene Glycol Monomethyl Ether 结构式
 BCP28370 五乙二醇单甲醚 23778-52-1
Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Mal-PEG1-PNP-carbonate 结构式
 BCP24746 Mal-PEG1-PNP-carbonate 1345681-74-4
Mal-PEG1-PNP-carbonate is a amine-reactive compound.
Cyanine5 amine 结构式
 BCP24921 Cyanine5 amine 1807589-58-7
Cyanine5 amine is a reactive dye which contains amino group, an analog of Cy5® amine. This reagent can be coupled with a variety of activated esters and other electrophilic reagents. For example, this amine can be coupled with EDC-activated carboxylic groups.
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