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PARP

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PARP

结构式 货号 产品名称 CAS号
WD2000-012547 结构式
 BCP24089 WD2000-012547 283172-68-9
WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.
MSC2504877 结构式
 BCP48087 MSC2504877 1460286-21-8
MSC2504877 is a novel tankyrase inhibitor, enhancing the effects of clinical cdk4/6 inhibitors.
RBN3143 结构式
 BCP47990 RBN3143 RBN3143
RBN-3143 is a PARP-14 inhibitor. PARP14 is over-expressed in tissues with inflammatory diseases.
E7016 结构式
 BCP46932 E7016 902128-92-1
E7016 is an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP mediated DNA repair of single strand DNA breaks via the base-excision repair pathway.
EB 47 结构式
 BCP46739 EB 47 366454-36-6
EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
KSQ-4279 结构式
 BCP46572 KSQ-4279 2446480-97-1
KSQ-4279 is a USP1 and PARP inhibitor.
Senaparib 结构式
 BCP44003 Senaparib 1401682-78-7
Senaparib is an orally bioavailable inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity.
NVP-TNKS656 结构式
 BCP28685 NVP-TNKS656 1419949-20-4
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2.
Venadaparib 结构式
 BCP42946 Venadaparib 1681017-83-3
Venadaparib is an antineoplastic.Venadaparib is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
RBN012759 结构式
 BCP42877 RBN012759 2360851-29-0
RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.
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