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Tivozanib 结构式

替沃扎尼

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货号 :BCP01980CAS号 :475108-18-0纯度:98%
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  • 基本信息与产品描述
CAS号 475108-18-0 货号 BCP01980
关联产品 682745-41-1(替沃扎尼盐酸盐一水合物)
中文名 替沃扎尼
英文名 Tivozanib
中文别名
英文别名 AV-951;AV951;AV 951; KRN951; KRN 951; KRN-951;
SMILES O=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2Cl
化学名称
分子式 C22H19ClN4O5 分子量 454.86
纯度 98% 配送 惯例下常温包邮
产品描述 Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.
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