替沃扎尼
CAS号 | 475108-18-0 | 货号 | BCP01980 |
中文名 | 替沃扎尼 | ||
英文名 | Tivozanib | ||
中文别名 | |||
英文别名 | AV-951;AV951;AV 951; KRN951; KRN 951; KRN-951; | ||
分子式 | C22H19ClN4O5 | 分子量 | 454.86 |
生物活性 | Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. | ||
上下游产品 | 682745-41-1(替沃扎尼盐酸盐一水合物) | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | PDGFR VEGFR |
结构式
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