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Ripretinib 结构式

瑞普替尼

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货号 :BCP29218CAS号 :1442472-39-0纯度:98%
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  • 基本信息与产品描述
CAS号 1442472-39-0 货号 BCP29218
中文名 瑞普替尼
英文名 Ripretinib
中文别名
英文别名 DCC 2618;DCC2618;KIT/PDGFR inhibitor;Ripretinib;
SMILES O=C(NC1=CC=CC=C1)NC2=CC(C3=CC4=C(N(CC)C3=O)C=C(NC)N=C4)=C(Br)C=C2F
化学名称
分子式 C24H21BrFN5O2 分子量 510.36
纯度 98% 配送 惯例下常温包邮
产品描述 Ripretinib, also known as DCC-2618, is a potent, orally active and selective KIT/PDGFR inhibitor with potential antineoplastic activity. DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. DCC-2618 also inhibits several other kinases, including vascular endothelial growth factor receptor type 2 (VEGFR2; KDR), angiopoietin-1 receptor (TIE2; TEK), PDGFR-beta and macrophage colony-stimulating factor 1 receptor (FMS; CSF1R), thereby further inhibiting tumor cell growth.
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