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CAS号 | 1032265-67-0 | 货号 | BCP25213 |
中文名 | SIM010603 | ||
英文名 | SIM010603 | ||
中文别名 | |||
英文别名 | SIM 010603; SIM-010603; | ||
SMILES | |||
化学名称 | |||
分子式 | C22H25FN4O2 | 分子量 | 396.46 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis. |
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