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Crenolanib besylate 结构式

Crenolanib besylate

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货号 :BCP24113CAS号 :670220-93-6纯度:98%
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  • 基本信息与产品描述
CAS号 670220-93-6 货号 BCP24113
中文名 Crenolanib besylate
英文名 Crenolanib besylate
中文别名
英文别名 Crenolanib besilate; CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002;
SMILES CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4.C1=CC=C(C=C1)S(=O)(=O)O
化学名称
分子式 C32H35N5O5S 分子量 601.72
纯度 98% 配送 惯例下常温包邮
产品描述 Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types.
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