即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 670220-93-6 | 货号 | BCP24113 |
中文名 | Crenolanib besylate | ||
英文名 | Crenolanib besylate | ||
中文别名 | |||
英文别名 | Crenolanib besilate; CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; | ||
SMILES | CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4.C1=CC=C(C=C1)S(=O)(=O)O | ||
化学名称 | |||
分子式 | C32H35N5O5S | 分子量 | 601.72 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types. |
相关产品推荐
查看更多 >Tags:Crenolanib besylate 供应商,Crenolanib besylate 购买,Crenolanib besylate 生产,Crenolanib besylate 批量,Crenolanib besylate 供应,Crenolanib besylate 订购,Crenolanib besylate 采购