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CAS号 | 682745-41-1 | 货号 | BCP45190 |
关联产品 | 475108-18-0(替沃扎尼) | ||
中文名 | 替沃扎尼盐酸盐一水合物 | ||
英文名 | Tivozanib hydrochloride hydrate | ||
中文别名 | 盐酸替沃扎尼一水合物; | ||
英文别名 | Tivozanib HCl H2O; | ||
SMILES | CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl.O.Cl | ||
化学名称 | |||
分子式 | C22H22Cl2N4O6 | 分子量 | 509.34 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. |
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