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Linsitinib 结构式

Linsitinib

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货号 :BCP01831CAS号 :867160-71-2纯度:98%
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  • 基本信息与产品描述
CAS号 867160-71-2 货号 BCP01831
中文名 Linsitinib
英文名 Linsitinib
中文别名
英文别名 OSI906;OSI 906;OSI-906;
SMILES
化学名称
分子式 C26H23N5O 分子量 421.49
纯度 98% 配送 惯例下常温包邮
产品描述 OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM.
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