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AG-1024 结构式

AG-1024

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货号 :BCP06692CAS号 :65678-07-1纯度:98%
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  • 基本信息与产品描述
CAS号 65678-07-1 货号 BCP06692
中文名 AG-1024
英文名 AG-1024
中文别名
英文别名 AG 1024;AG1024; Tyrphostin AG 1024;
SMILES
化学名称
分子式 C14H13BrN2O 分子量 305.17
纯度 98% 配送 惯例下常温包邮
产品描述 AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG1024 decreases Ang II-mediated NAD(P)H oxidase activation.
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