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CAS号 | 477-47-4 | 货号 | BCP18482 |
中文名 | 苦鬼臼素 | ||
英文名 | Picropodophyllin | ||
中文别名 | 苦鬼臼脂素; | ||
英文别名 | (-)PPP;AXL1717; AXL-1717; AXL 1717; PPP; Picropodophyllotoxin; | ||
SMILES | |||
化学名称 | |||
分子式 | C22H22O8 | 分子量 | 414.41 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AXL1717, also known as Picropodophyllotoxin, Picropodophyllin or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. |
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