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| CAS号 | 475488-23-4 | 货号 | BCP27617 |
| 中文名 | NVP-ADW742 | ||
| 英文名 | NVP-ADW742 | ||
| 中文别名 | |||
| 英文别名 | ADW; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C28H31N5O | 分子量 | 453.58 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells. | ||
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