Linsitinib
CAS号 | 867160-71-2 | 货号 | BCP01831 |
中文名 | Linsitinib | ||
英文名 | Linsitinib | ||
中文别名 | |||
英文别名 | OSI906;OSI 906;OSI-906; | ||
分子式 | C26H23N5O | 分子量 | 421.49 |
生物活性 | OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | Insulin Receptor IGF1R |
结构式
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