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NVP-ADW742 结构式

NVP-ADW742

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP01826CAS号 :475488-23-4纯度:98%
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  • 基本信息与产品描述
CAS号 475488-23-4 货号 BCP01826
中文名 NVP-ADW742
英文名 NVP-ADW742
中文别名
英文别名 ADW; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A;
SMILES
化学名称
分子式 C28H31N5O 分子量 453.58
纯度 98% 配送 惯例下常温包邮
产品描述 NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells.
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