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GSK 621659A 结构式

GSK 621659A

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货号 :BCP25985CAS号 :475489-15-7纯度:98%
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  • 基本信息与产品描述
CAS号 475489-15-7 货号 BCP25985
中文名 GSK 621659A
英文名 GSK 621659A
中文别名
英文别名 NVP-ADW742;ADW-742;
SMILES C1CCN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6
化学名称
分子式 C28H31N5O 分子量 453.58
纯度 98% 配送 惯例下常温包邮
产品描述 GSK 552602A is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells.
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