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Sunitinib 结构式

苏尼替尼

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货号 :BCP02336CAS号 :557795-19-4纯度:98%
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  • 基本信息与产品描述
CAS号 557795-19-4 货号 BCP02336
关联产品 341031-54-7(苏尼替尼苹果酸盐)
中文名 苏尼替尼
英文名 Sunitinib
中文别名 舒尼替尼;
英文别名 SU-11248;SU 11248;SU11248;SU-011248;SU011248;SU 011248;
SMILES CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
化学名称
分子式 C22H27FN4O2 分子量 398.48
纯度 98% 配送 惯例下常温包邮
产品描述 Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with Ki of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and src. In serum-starved NIH-3T3 cells expressing VEGFR2 or PDGFRβ, Sunitinib inhibits VEGF-dependent VEGFR2 phosphorylation and PDGF-dependent PDGFRβ phosphorylation with IC50 of 10 nM and 10 nM, respectively. Sunitinib inhibits VEGF-induced proliferation of serum-starved HUVECs with IC50 of 40 nM, and inhibits PDGF-induced proliferation of NIH-3T3 cells overexpressing PDGFRβ or PDGFRα with IC50 of 39 nM and 69 nM, respectively. SU11248 also has potent activity against wild-type FLT3 (FLT3-WT), FLT3-ITD, and FLT3 activation loop (FLT3-Asp835) mutants in phosphorylation assays. SU11248 inhibits FLT3-driven phosphorylation and induces apoptosis in vitro. In addition, SU11248 inhibits FLT3-induced VEGF production .
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