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TAS-115 结构式

TAS-115

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货号 :BCP34014CAS号 :1190836-34-0纯度:98%
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  • 基本信息与产品描述
CAS号 1190836-34-0 货号 BCP34014
中文名 TAS-115
英文名 TAS-115
中文别名
英文别名 TAS 115, TAS115; Pamufetinib;
SMILES CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F
化学名称
分子式 C27H23FN4O4S 分子量 518.56
纯度 98% 配送 惯例下常温包邮
产品描述 TAS-115 is a c-MET Inhibitor. TAS-115 inhibited the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. TAS-115 is extremely selective and specific, at least in vitro. In in vivo studies, TAS-115 completely suppressed the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. TAS-115 induced marked tumor shrinkage and prolonged survival in MET-amplified human cancer-bearing mice. TAS-115 is a unique VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity.
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