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CAS号 | 1190836-34-0 | 货号 | BCP34014 |
中文名 | TAS-115 | ||
英文名 | TAS-115 | ||
中文别名 | |||
英文别名 | TAS 115, TAS115; Pamufetinib; | ||
SMILES | CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F | ||
化学名称 | |||
分子式 | C27H23FN4O4S | 分子量 | 518.56 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | TAS-115 is a c-MET Inhibitor. TAS-115 inhibited the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. TAS-115 is extremely selective and specific, at least in vitro. In in vivo studies, TAS-115 completely suppressed the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. TAS-115 induced marked tumor shrinkage and prolonged survival in MET-amplified human cancer-bearing mice. TAS-115 is a unique VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity. |
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